(R)-3-AMINO-3-[2-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID

(R)-3-AMINO-3-[2-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID - Names and Identifiers

Name	R-3-Amino-3-(2- trifluoromethyl -phenyl)-propionic acid
Synonyms	H-D-b-Phe(2-CF3)-OH H-D-BETA-PHE(2-CF3)-OH H-PHG(2-CF3)-(C*CH2)OH L-BETA-HOMO(2-TRIFLUOROMETHYLPHENYL)GLYCINE 3-AMINO-3-[2-(TRIFLUOROMETHYL)PHENYL]PROPAN-1-OL R-3-Amino-3-(2- trifluoromethyl -phenyl)-propionic acid (R)-3-AMINO-3-(2-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID (R)-3-AMINO-3-[2-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID (3R)-3-aMino-3-[2-(trifluoroMethyl)phenyl]propanoic acid
CAS	791582-16-6

(R)-3-AMINO-3-[2-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID - Physico-chemical Properties

Molecular Formula	C10H10F3NO2
Molar Mass	233.19
Density	1.361±0.06 g/cm3(Predicted)
Boling Point	308.7±42.0 °C(Predicted)
pKa	3.55±0.10(Predicted)
Storage Condition	2-8°C

(R)-3-AMINO-3-[2-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID - Introduction

R-3-Amino-3-(2- trifluoromethyl -phenyl)-propionic acid, also known as R-ATFMPA, is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: Colorless crystalline solid.
-Melting point: about 151-154°C.
-Solubility: Soluble in alcohol and some organic solvents.
-Chemical structure: The chemical formula is C10H9F3NO2 and the molecular weight is 239.18g/mol.

Use:
- R-3-Amino-3-(2- trifluoromethyl -phenyl)-propionic acid is widely used as a synthetic intermediate for chiral compounds in the pharmaceutical field.
-It can be used to synthesize biologically active molecules and drugs.

Preparation Method:
- R-3-Amino-3-(2- trifluoromethyl -phenyl)-propionic acid can be synthesized by the following steps:
1. Synthesis of enantioselective reducing agents-such as sodium dihydride or ferrous hydride-selective reduction of related ketone compounds.
2. The obtained alcohol is reacted with the corresponding acid chloride to obtain the corresponding acid anhydride.
3. Condensation reaction of acid anhydride and amino acid using amino acid catalyst.
4. Purify the obtained chiral product by crystallization.

Safety Information:
- R-3-Amino-3-(2- trifluoromethyl -phenyl)-Specific safety information for propionic acid may depend on its purity and area of application.
-In handling and storage, the relevant chemical safety guidelines and operating procedures should be followed.
-Avoid inhalation, ingestion or skin contact. In the event of inhalation, ingestion or skin contact, seek medical assistance and provide information immediately.

Please note that the above information is for reference only. Specific chemical properties and safety information should be based on reliable laboratory manuals, safety data sheets provided by chemical suppliers and relevant regulations.

Last Update：2024-04-09 15:18:01